Retin-A (tretinoin topical) is a form of vitamin A that has been specially designed for topical use and is applied regularly to keep acne under control. Always take Retin-A exactly as prescribed, eve if you do not notice the improvement right away. Up to several weeks may be required for you to see the improvement. When you use Retin-A for the first time, an irritation may occur. However, the irritation may be a sign of your skin adjusting the medication. If the irritation does not go away - make sure you talk to your heath care provider about it. This drug is FDA pregnancy category C - it is not known for sure whether it can harm an unborn baby and should be therefore used with a lot of caution. Your health care provider will need to know if you are taking any other medications at the moment (such as chlorpromazine, diuretics, fluphenazine, antibiotics, sulfa drugs etc) to prescribed the right way of treatment and make sure no interactions will occur. There is no need to worry if during first applications of Retin-A you experience irritation, itching, redness, skin discoloration, dryness, stinging, tingling, warmth, burning, swelling, or peeling - those are normal reactions of your skin and they will most probably go away on their own very soon.